Recherche scientifique et médicale
Notre service est très actif dans la recherche aussi bien translationnelle que clinique. Notre unité de recherche fait partie de l’unité INSERM UMR 1152 (physiopathologie et épidémiologie des maladies respiratoires)
Les principales thématiques sont :
L’atteinte pulmonaire au cours de la polyarthrite rhumatoïde
o Baseline characteristics of the TRANSLATE2 cohort: A prospective study on rheumatoid arthritis-associated interstitial lung disease
o MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease
o A Risk Score to Detect Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease
o MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression
o Methotrexate and rheumatoid arthritis associated interstitial lung disease
o Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis
o RPA3-UMAD1 rs12702634 and rheumatoid arthritis-associated interstitial lung disease in European ancestry
o Value of lung ultrasonography for screening interstitial lung disease in patients with rheumatoid arthritis
o Effectiveness and tolerability of antifibrotics in rheumatoid arthritis-associated interstitial lung disease
Spondylarthrite et rhumatisme psoriasique
o Evaluation of pregnancy outcomes in patients with spondyloarthritis compared to the general population: results from a French national prospective and matched study.
o Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints (DAPSA44).
o Evaluation of instruments assessing peripheral arthritis in spondyloarthritis: an analysis of the ASAS-PerSpA study.
o Disease activity during pregnancy in patients with rheumatoid arthritis or spondyloarthritis: results from the multicentre prospective GR2 study.
o Sacroiliac radiographic progression over 10 years in axSpA: data from the DESIR inception cohort.
o Different disease activity trajectories in early axial spondyloarthritis lead to significantly different long-term outcomes: a trajectory-based analysis of the DESIR cohort over 10 years.
o Evaluation of long-term TNFi effectiveness after a first switch in early axial spondyloarthritis considering time-varying prescription bias: an inverse-probability weighting analysis of the DESIR cohort.
o Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial.
L’imagerie au cours des rhumatismes inflammatoires et microcristallin
o Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography in polymyalgia rheumatica: an observational study
o Salivary gland ultrasonography in patients with connective tissue diseases: a multi-centre observational study
o Ultrasound evaluation in follow-up of urate-lowering therapy in gout: the USEFUL study
o UltraSound evaluation in follow-up of urate-lowering therapy in gout phase 2 (USEFUL-2): Duration of flare prophylaxis
o Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study
o Ankle retinacula abnormalities as features of psoriatic arthritis: An ultrasound study
Autres
o Screening for spondyloarthritis in patients with inflammatory bowel diseases
o Increased risk of mortality in lung transplant patients with fragility fractures
o Osteoporotic vertebral fracture during non-small cell lung cancer – the BONE study
o A disseminated gonococcal infection with spinal locations
o Cardiac myxoma mimicking a spondyloarthritis flare.
Par ailleurs, nous participons activement à de nombreux protocoles de recherche clinique et registres, dans le domaine des rhumatismes inflammatoires, microcristallins et connectivite.
Bureau de Recherche Clinique :
Hagit ZYLBERMAN-YONA
Tel 01 40 25 70 27